Edinburgh 23rd September 2020 It is with great sadness that DESTINA Genomics and DESTINA Genomica announce the death of our friend, colleague and CEO Hugh Ilyine. Hugh was found at his desk having only recently been on a call where he had been his usual ebullient and energetic self. Hugh was a founding director and…
DESTINA Genomica SL has joined @Science Exchange, the global platform for outsourced R&D reagents and services. For quotations on the supply of RNA profiling services and custom PNAs synthesis for your research, just contact us via our website. Orders on acceptance can then be made securely through https://www.scienceexchange.com/labs/destina-genomica-sl
DESTINA Genomics has a new redesigned and upgraded website at www.destinagenomics.com Now live, the modernised web design makes access easy to our product and services for PCR free, highly accurate and quantifiable detection of RNA Biomarkers. DESTINA’s unique patented chemistry and how it works is now explained using a 3D Video, with a dynamic new…
On 20th February 2020 at 9:30am GMT, Hugh Ilyine will present, during the New Biomarker Technologies & Data Session, the integration of DESTINA Chemistry within Merck SMCxPro platform for quantifying miRNA molecules directly from body fluids. The title of his talk is Novel Single Molecule Counting (SMC) Of MicroRNA By A PCR Free Method. See…
Citation: Analytical Chemistry, 2020, doi: 10.1021/acs.analchem.9b05449 Abstract Circulating microRNAs are biomarkers reported to be stable and translational across species. MicroRNA-122 (miR-122) is a hepatocyte-specific microRNA biomarker for drug-induced liver injury (DILI). We developed a single molecule, dynamic chemical labeling (DCL) assay to directly detect miR-122 in blood. The DCL assay specifically measured miR-122 directly from 10…
Citation: IEEE Access, 2019, 7, 185677 – 185686 DOI:10.1109/ACCESS.2019.2961230 Abstract A smartphone-based platform for the diagnosis of parasitic infections has been developed, tested and validated. The system is capable of making automatic and accurate analysis of millimetric colorimetric arrays in centrifuge collection tubes, which are well established tools used in clinical analysis. To that end, an Android-based…
Citation: Chem. Commun., 2019, 55, 14958-14961 Abstract A simple method for direct detection of microRNAs (miRs) in human serum without the use of polymerase amplification is presented, achieving low miR-122 concentrations and importantly, discerning effectively single-base sequence mutations. The method is based on the capture of target miRs with synthetic peptide nucleic acid oligomers, dynamic chemical labelling,…
Citation: Talanta, 2019, 51-56 Abstract miRNAs are well known for being implicated in a myriad of biological situations, including those related to serious diseases. Amongst miRNAs, miRNA-21 has the spotlight as it is reported to be up-regulated in multiple severe pathological conditions, being its quantification a key point in medicine. To date, most of the techniques for miRNA quantification…
Citation: Anal. Chem., 2019, 91 (9), 5874–5880 Abstract Circulating microRNAs have been identified as potential biomarkers for early detection, prognosis, and prediction of several diseases. Their use in clinical diagnostics has been limited by the lack of suitable detection techniques. Most of the current technologies suffer from requiring complex protocols, not yet able to deliver robust and cost-effective…
Citation: In: Pedras B. (eds) Fluorescence in Industry. Springer Series on Fluorescence (Methods and Applications), vol 18. Springer, Chamger Ser Fluoresc, DOI 10.1007/4243_2018_4 Abstracts Luminescence emission is a multidimensional phenomenon comprising a time-domain layer defined by its excited-state kinetics and corresponding lifetime, which is specific to each luminophore and depends on environmental conditions. This feature…