DESTINA Genomics and Mecwins join forces to develop more reliable diagnostic tests

DESTINA Genomics and Mecwins join forces to develop more reliable diagnostic tests   Both biotechnology firms have signed a cross-licensing agreement to share technology to develop RNA quantification tests directly from biological samples. Initial tests will focus both on RNA biomarkers for drug-induced hepatotoxicity, nephrotoxicity and cardiotoxicity, and on therapeutic RNAs.  Thanks to the combination…

DESTINA featuring at Virtual Symposium On Ultrasensitive Immunoassays: The Power of Single Molecule Counting (SMC™) Technology organised by MilliporeSigma

On Wednesday 31 March 2021, DESTINA’s Juan Jose Diaz-Mochon will present the First Single Molecule Counting (SMC™) Application with miRNAs by a PCR Free Method. You can register here to watch the presentation https://lnkd.in/eiMknq9 The high specificity of DESTINA technologies has been implemented within the ultrasensitive SMC™ to yield the platform’s first molecular assays. During his presentation, Juan…

Amplification-free profiling of microRNA-122 biomarker in DILI patient serums, using the Luminex MAGPIX system

Citation: Talanta, 2020, doi: 10.1016/j.talanta.2020.121265 Abstract Dynamic chemical labelling is a single-base specific method to enable detection and quantification of micro-Ribonucleic Acids in biological fluids without extraction and pre-amplification. In this study, dynamic chemical labelling was combined with the Luminex MAGPIX system to profile levels of microRNA-122 biomarker in serum from patients with Drug-Induced Liver Injury.

Direct Detection of miR-122 in Hepatotoxicity Using Dynamic Chemical Labeling Overcomes Stability and isomiR Challenges

Citation: Analytical Chemistry, 2020, doi: 10.1021/acs.analchem.9b05449 Abstract Circulating microRNAs are biomarkers reported to be stable and translational across species. MicroRNA-122 (miR-122) is a hepatocyte-specific microRNA biomarker for drug-induced liver injury (DILI). We developed a single molecule, dynamic chemical labeling (DCL) assay to directly detect miR-122 in blood. The DCL assay specifically measured miR-122 directly from 10…

Smartphone-Based Diagnosis of Parasitic Infections With Colorimetric Assays in Centrifuge Tubes

Citation: IEEE Access, 2019, 7, 185677 – 185686 DOI:10.1109/ACCESS.2019.2961230 Abstract A smartphone-based platform for the diagnosis of parasitic infections has been developed, tested and validated. The system is capable of making automatic and accurate analysis of millimetric colorimetric arrays in centrifuge collection tubes, which are well established tools used in clinical analysis. To that end, an Android-based…