Short communication: miRNA122 interrogation via PCR-Free method to track liver recovery

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Citation: PLoS One 20(5): e0324858. DOI: 10.1371/journal.pone.0324858 Abstract There is currently a need to investigate new biomarkers of acute liver injury (ALI) that are highly specific to the liver and capable of detecting early-stage liver damage. In this regard, circulating microRNAs (miRNAs), particularly microRNA122 (miRNA122), have recently been proposed as promising new candidate biomarkers. However,…

Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA-122 in hospital clinical laboratories

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Citation: Br J Clin Pharmacol. 2025; 1-7 DOI: 10.1002/bcp.70364 Abstract MicroRNA-122 (miR-122) is a sensitive biomarker for paracetamol-induced liver injury. This study assessed the diagnostic performance of dynamic chemical labelling (DCL) combined with an immunoassay platform to quantify miR-122 in human serum, as a proof-of-concept for hospital use. This study used serum samples from 19 healthy individuals…

The European Comission award DESTINA the diar

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Technology The three major DESTINA technologies are unique and distinguishable from ALL existing enzymatic methods of nucleic acid analysis. DGL-TechTM DGL-TechTM for nucleic acid analysis combines patented SMART-Bases with unique peptide nucleic acid (PNA) capture ChemiRNATM Tech ChemiRNATM Tech are small non-coding RNAs of 19–24 nucleotides in length with a big role in gene regulation Spin-Tube device…

Evaluation of diagnostic and prognostic candidate biomarkers in drug-induced liver injury vs. other forms of acute liver damage

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Citation: Br J Clin Pharmacol. 2023; 89:2497–2507 DOI:10.1111/bcp.15724 Abstract Aims Detection and characterization of idiosyncratic drug-induced liver injury (DILI) currently rely on standard liver tests, which are suboptimal in terms of specificity, sensitivity and prognosis. Therefore, DILI diagnosis can be delayed, with important consequences for the patient. In this study, we aimed to evaluate the…

MAGPIX and FLEXMAP 3D Luminex platforms for direct detection of miR-122-5p through dynamic chemical labelling

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Citation: Analyst, 2023, Advance Article DOI: 10.1039/D3AN01250F Abstract MicroRNAs (miRs) have emerged as promising biomarkers for diagnosing and predicting the prognosis of liver injury. This study aimed to compare the performance of two Luminex platforms, MAGPIX and FLEXMAP 3D, utilizing the innovative Dynamic Chemical Labelling (DCL) technology for direct detection and analysis of miR-122-5p in…

Diagnosing Alzheimer’s Disease – Project granted with more than €1.3 million in aid under the Colaboración Público Privada Program

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Destina Genomica SL is part of a consortium formed by the Foundation for Biomedical Research of the Ramón y Cajal University Hospital (Madrid, Spain), the Advanced Photonic and Biofunctional Materials Group of the UAM (Autonomous University of Madrid, Spain) and led by the Spanish company Mecwins SA (Madrid) that has just received a grant of…

OPEN A NEW WINDOW ON THE WORLD OF CIRCULATING MICRORNA BIOMARKERS BY MERGING CHEMIRNATM TECH WITH AVAC ANALYZER

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We are excited to announce a new project that changes the way we analyze miRNA-122. This small non-coding RNA is known as a biomarker for liver injury. With the support of the 2022 ICEX-Invest in Spain’s funding program, we are implementing the unique PCR-Free testing of miRNA-122 using DESTINA’s ChemiRNATM Tech reagents merged with AVAC…