LiverAce™ COMBO Kit

The only multiplex panel that combines PCR-Free detection of the early-detection biomarker miRNA-122 with the mechanistic biomarker Cytokeratin-18 (M65) in a single assay.

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Key Features

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Simultaneous Multiplexing: Quantify both miRNA-122 & K18 from one sample.
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PCR-Free Workflow: No extraction, no reverse transcription, and no amplification.
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Complete Kit: Includes two 96-well plates, all reagents, and calibrators for absolute quantification.

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Low Sample Volume: Requires only 25 µL of serum or plasma.
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Fast Turnaround: Go from sample to result in under 5 hours.
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Luminex xMAP® Ready: Fully validated for all Luminex platforms (MAGPIX®, FLEXMAP 3D®, etc.).

Product Characteristics

Kit Specifications

Parameter	Value
Analytes	miRNA-122 & Cytokeratin-18 (M65)
Platform	Luminex xMAP® (Validated on MAGPIX®, etc.)
Detection Method	PCR-Free Dynamic Chemical Labelling (DCL)
Time to Result	< 5 Hours
Sample Volume	25 µL
Sample Type	Serum, Plasma
Quantification Range	Absolute (Calibrators included)

Performance Characteristics

Assay Sensitivity

Analyte	LOD (pg/mL)	LLOQ (pg/mL)
K18	60	137
miR-122	2.4	20.58

Precision

Analyte	Intra-assay %CV	Inter-assay %CV
K18	< 15%	< 25%
miR-122	< 15%	< 25%

Assay Procedure

Simple, Streamlined, Superior

1. Add Sample

2. Capturing & Hybridizing

3. Label

4. Read

Applications & Research Fields

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Pharma R&D & Drug Development
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CROs & Service Labs
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Preclinical Safety Assessment
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Liver Toxicity (DILI) Screening

Documentation

To ensure you receive the latest version of our documentation, these files are available upon request.

Product Brochure (PDF)

Scientific Proof

Review the clinical evidence supporting our biomarkers and the DCL technology powering the LiverAce™ assays.

Key Publications (Biomarkers)

Clinical evidence supporting miR-122 and Keratin-18 as superior biomarkers for drug-induced liver injury.

Key Publications (LiverAce™ on Luminex platforms)

Foundational papers on the Dynamic Chemical Labelling (DCL) technology that powers LiverAce™ assays on Luminex platforms.

Ready to Transform Your Liver Safety Assessment?

Contact our specialists to discuss your research needs, request a quote, or inquire about our free evaluation kits.

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