The Power Behind PCR-Free Diagnostics

Our platform-agnostic chemistry transforms standard immunoassay platforms into high-value workstations. By enabling direct, extraction-free detection of miRNAs, isomiRs, and proteins on any reader, Destina Chemistry provides the bridge between proteomics and the future of RNA therapeutics.

Key Values

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miRNA Detection Using Immunoassay Workflows

Platform-Agnostic Chemistry

Biomarker-Agnostic Scalability

Expands Utility of Existing Platforms

Single-Well Multi-Omic

Opportunities for Impactful Assays

Bridge to RNA Therapeutics

Destina Chemistry (DGL-Tech): The Core Chemistry

DGL-Tech for nucleic acid analysis combines patented SMART-Bases with unique peptide nucleic acid (PNA) capture probes with ‘blank’ positions (DGL-Probes).

The revolutionary DGL-Tech works thanks to Watson-Crick base pairing (C-G/A-T) that enables the templating of a dynamic reaction on the DGL-Probe.

1. The DGL-Probe hybridises with a complementary Nucleic Acid Target, creating a Chemical Pocket containing the Unknown Nucleotide under interrogation.

2. In the presence of four SMART-Bases (i.e. adenine, thymine guanine and cytosine) the Chemical Pocket creates reversible iminium intermediates between the aldehyde chemical group on the SMART-Bases and the amino group on the blank position.

3. The Unknown Nucleotide stabilises the iminium intermediate formed with the complementary SMART-Base. The most stable iminium intermediate is thus reduced (Chemical Lock-up) and analysed.

ChemiRNA Tech: The miRNA Application

Profiling of miRNAs is one of the most active areas of research in the field of liquid biopsy. DESTINA offers a new way to interrogate sequences of miRNAs through its unique ChemiRNA Tech.

ChemiRNA Tech is based on DESTINA DGL-Tech for the direct detection and quantification of miRNAs in body fluids. It uses a single biotinylated SMART-Base to label the duplex formation with miRNA sequences.

The technology includes DESTINA proprietary Stabiltech buffer that allows the liberation and stabilisation of RNAs in body fluids, and at the same time removes the need for refrigerated handling up to the analysis.

1. The DGL-Probe captures the complementary miRNA sequence, forming the Chemical Pocket. When the target miRNA hybridisation is complete, the biotinylated SMART-Base is covalently attached to the backbone of the DGL-Probe (Chemical Lock-up).

2. The duplex is read out using a Reporter Molecule that recognise the biotin tag.

Get Started with Destina Chemistry

We are seeking strategic partners to deploy our validated technology. Stop competing on standard assays and start offering exclusive, high-value diagnostics.

For Researchers (Pharma/Biotech)

See this technology in action. Test our validated, ready-to-use LiverAce™ Kits for DILI safety assessment today.

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For Partners (CROs/Diagnostics)

License our Destina Chemistry to create your own novel, PCR-Free assays. Gain a competitive advantage in the biomarker market.

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Let's Change the Future of Nucleic Acid Diagnostics

Contact Destina today to discuss licensing or partnership opportunities and gain a definitive competitive advantage in the biomarker market.

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