LiverAce™ COMBO Kit
The only multiplex panel that combines PCR-Free detection of the early-detection biomarker miRNA-122 with the mechanistic biomarker Cytokeratin-18 (M65) in a single assay.
Key Features
- Simultaneous Multiplexing: Quantify both miRNA-122 & K18 from one sample.
- PCR-Free Workflow: No extraction, no reverse transcription, and no amplification.
- Complete Kit: Includes two 96-well plates, all reagents, and calibrators for absolute quantification.
- Low Sample Volume: Requires only 25 µL of serum or plasma.
- Fast Turnaround: Go from sample to result in under 5 hours.
- Luminex xMAP® Ready: Fully validated for all Luminex platforms (MAGPIX®, FLEXMAP 3D®, etc.).
Product Characteristics
Kit Specifications
| Parameter | Value |
|---|---|
| Analytes | miRNA-122 & Cytokeratin-18 (M65) |
| Platform | Luminex xMAP® (Validated on MAGPIX®, etc.) |
| Detection Method | PCR-Free Dynamic Chemical Labelling (DCL) |
| Time to Result | < 5 Hours |
| Sample Volume | 25 µL |
| Sample Type | Serum, Plasma |
| Quantification Range | Absolute (Calibrators included) |
Performance Characteristics
Assay Sensitivity
| Analyte | LOD (pg/mL) | LLOQ (pg/mL) |
|---|---|---|
| K18 | 60 | 137 |
| miR-122 | 2.4 | 20.58 |
Precision
| Analyte | Intra-assay %CV | Inter-assay %CV |
|---|---|---|
| K18 | < 15% | < 25% |
| miR-122 | < 15% | < 25% |
Assay Procedure
Simple, Streamlined, Superior
1. Add Sample
2. Capturing & Hybridizing
3. Label
4. Read
Applications & Research Fields
- Pharma R&D & Drug Development
- CROs & Service Labs
- Preclinical Safety Assessment
- Liver Toxicity (DILI) Screening
Documentation
Scientific Proof
Review the clinical evidence supporting our biomarkers and the DCL technology powering the LiverAce™ assays.
Key Publications (Biomarkers)
Clinical evidence supporting miR-122 and Keratin-18 as superior biomarkers for drug-induced liver injury.
Key Publications (LiverAce™ on Luminex platforms)
Foundational papers on the Dynamic Chemical Labelling (DCL) technology that powers LiverAce™ assays on Luminex platforms.
Ready to Transform Your Liver Safety Assessment?
Contact our specialists to discuss your research needs, request a quote, or inquire about our free evaluation kits.