Short communication: miRNA122 interrogation via PCR-Free method to track liver recovery

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Citation: PLoS One 20(5): e0324858. DOI: 10.1371/journal.pone.0324858 Abstract There is currently a need to investigate new biomarkers of acute liver injury (ALI) that are highly specific to the liver and capable of detecting early-stage liver damage. In this regard, circulating microRNAs (miRNAs), particularly microRNA122 (miRNA122), have recently been proposed as promising new candidate biomarkers. However,…

Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA-122 in hospital clinical laboratories

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Citation: Br J Clin Pharmacol. 2025; 1-7 DOI: 10.1002/bcp.70364 Abstract MicroRNA-122 (miR-122) is a sensitive biomarker for paracetamol-induced liver injury. This study assessed the diagnostic performance of dynamic chemical labelling (DCL) combined with an immunoassay platform to quantify miR-122 in human serum, as a proof-of-concept for hospital use. This study used serum samples from 19 healthy individuals…

The European Comission award DESTINA the diar

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Technology The three major DESTINA technologies are unique and distinguishable from ALL existing enzymatic methods of nucleic acid analysis. DGL-TechTM DGL-TechTM for nucleic acid analysis combines patented SMART-Bases with unique peptide nucleic acid (PNA) capture ChemiRNATM Tech ChemiRNATM Tech are small non-coding RNAs of 19–24 nucleotides in length with a big role in gene regulation Spin-Tube device…